Non-IgE-mediated food allergies can be subdivided into different entities: food protein-induced enterocolitis syndrome or FPIES, food protein-induced allergic proctocolitis or FPIAP, food protein-induced enterophathy or FPE, food protein-induced motility disorders (FPIMD) such as gastro-esophageal reflux disease (GERD), colic and constipation, and eosinophilic gastrointestinal disorders (EGIDs) such as eosinophilic esophagitis (EoE), eosinophilic gastroenteritis (EGE), eosinophilic enteritis and eosinophilic colitis (EC). This evidence concerns the gene IGHE and food allergy.