In EoE it is known that single nucleotide polymorphisms (SNPs) in genes encoding for thymic stromal lymphopoietin (TSLP), calpain 14 protease (CAPN14), IL-1 family genes, serine peptidase inhibitors (SERPINs), serine protease inhibitors or Kazal-type-related inhibitors (SPINKs) are associated with an increased risk of EoE (64, 69). The gene discussed is CAPN14; the disease is eosinophilic esophagitis.