Serum IgA2 anti-dsDNA antibody concentrations were significantly higher in patients with active renal disease than in those without active renal disease in both the BEAT-LUPUS and the independent organ involvement validation cohort, whereas serum IgM anti-dsDNA antibody concentrations were lower in those with active renal disease in both patient cohorts (appendix p 28). Here, CD40LG is linked to kidney disorder.