In tight consistency, the increased infection of the Nd virion by the NAs treatments (Figure 5) that significantly enhanced the endosomal accumulation of the incoming virion (Figure 6 and Supplementary Figure S5C) quantitatively correlated with the extent of VP2-Nt cleavage (Figure 7B) and the VP1-Nt exposure in the endosomal clusters (Figure 7C). The gene discussed is NDP; the disease is infection.