MAPT and early-onset autosomal dominant Alzheimer disease: As reported in human Alzheimer’s disease, tau transgenic Drosophila (Frost et al., 2016; Cornelison et al., 2019), induced pluripotent stem cell (iPSC)-derived neurons harboring disease-associated tau (MAPT) mutations (Paonessa et al., 2019), and primary neurons with induced tau aggregation (Jiang and Wolozin, 2021) we find that induced expression of pathogenic tau is sufficient to drive the formation of nuclear envelope invaginations and blebs in iTau cells (Figure 2B).