Consistent with previous work in Drosophila, iPSC-derived neurons from patients harboring MAPT mutations, cultured primary cortical neurons with induced tau oligomerization, induced tau expression in HEK293 cells, and postmortem human Alzheimer’s disease brain tissue (Frost et al., 2016; Montalbano et al., 2019; Paonessa et al., 2019; Jiang and Wolozin, 2021), we observe a significant increase of nuclear invaginations and blebbing in cultured neuroblastoma cells with induced tau expression compared to controls. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.