MAPT and early-onset autosomal dominant Alzheimer disease: In addition to nuclear pleomorphisms in human Alzheimer’s disease brain and in tau transgenic Drosophila, neuronal nuclei affected by tau have overall reduced levels of the B-type lamins (Frost et al., 2016), proteins that form intermediate filaments that line the internal surface of neuronal nuclei that are critical to establish nuclear structure and strength (Worman, 2012).