ACE and early-onset autosomal dominant Alzheimer disease: It has also been suggested that ACE1 influences age-related diseases (i.e., Alzheimer’s disease—AD, sarcopenia, cancer) (Hu et al., 1999; Kehoe et al., 1999; Carl-McGrath et al., 2004; Yoshihara et al., 2009; Zhang et al., 2019; MacLachlan et al., 2022).