FKBP14 and Ehlers-Danlos syndrome, kyphoscoliotic type 1: In kyphoscoliotic EDS (kEDS; OMIM 225400), deficiency in lysyl hydroxylase (PLOD1) or FKBP22 protein (FKBP14) cause the destabilization of intermolecular collagen crosslinking and folding (6).