MAGE-TRIM28 axis also affects the Warburg effect and HCC progression by targeting fructose-1,6-biphosphatase (FBP1) and promoting its degradation, suggesting that MAGE-TRIM28 axis regulates the metabolic reprogramming of cancer cells by modulating the protein degradation of various metabolic regulators (47). The gene discussed is TRIM28; the disease is hepatocellular carcinoma.