There is also a link between MMP11 and EGFR, for example, increased EGFR phosphorylation results in upregulation of MMP11 expression that leads to increased migration, invasion and metastasis of breast cancer cells (57).Whereas in EGFR-mutant NSCLC cells overexpressing IGF-1R, inhibition of IGF-1R attenuates cell proliferation and VEGF production (58). This evidence concerns the gene MMP11 and breast cancer.