Accordingly, we propose that the immune microenvironment of LUAD differs with different levels of MMP11 expression and that high expression of MMP11 results in a downregulation of the abundance of immune cells that contributes to the antitumor effect and an upregulation of the abundance of immune cells that do not, both of which may make LUAD tumor cells more susceptible to immune escape. This evidence concerns the gene MMP11 and neoplasm.