TACR3 and Anxiety: Thus, the whole-cell patch clamp recording data suggest that LHb neurons were activated after pT-ION and that pharmacological activation of NK3R in the LHb neurons could suppress the abnormal excitation, thus indicating that pharmacological activation of NK3R in the LHb neurons reversed pT-ION-induced orofacial allodynia and pain associated anxiety-like behaviors by suppressing the abnormal excitation of LHb neurons.