NK3R has been reported to serve as a postsynaptic receptor as well as a presynaptic autoreceptor and heteroreceptor in the globus pallidus of the squirrel monkey (75), and NKB/NK3R signalling stimulates dopamine transmission at the presynaptic site under normal conditions but not in Parkinson’s disease (73). The gene discussed is TACR3; the disease is Parkinson disease.