Maternal deprivation induces LHb hyperactivity through glutamatergic synaptic potentiation that shifts the excitation/inhibition (E/I) balance towards excitation and shows changes in the relative weights of both increased excitatory and decreased inhibitory synaptic inputs onto LHb neurons, and thus produces anxiety-like and depression-like behaviors in adolescent male rats (76). This evidence concerns the gene LHB and major depressive disorder.