TACR3 and Anxiety: In our previous work, microarray analysis showed that the expression of Tacr3 was downregulated in the LHb of pT-ION mice (19), and we confirmed here that reversing the downregulation of Tacr3 in the bilateral LHb alleviated pT-ION-induced orofacial allodynia (Figures 10E–G) and pain-related anxiety-like behaviors (Figures 10K–N; Figure S6A).