From the perspectives of the immune score, stromal score, tumor purity, tumor-infiltrating immune cell abundance, immune regulators, immune-related pathways, immune signatures, tumor mutational burden (TMB), microsatellite instability (MSI), mismatch repair (MMR) ability, the proportion of somatic mutations and subtype analysis, we confirmed that COAD patients with high autophagy score or high IFNG expression would benefit more from immune blocking therapy. Here, IFNG is linked to colon adenocarcinoma.