TF and Sepsis: Pyroptosis has displayed a prominent role in hemostasis imbalance and “immunothrombosis” in sepsis: it participates in regulating the release and activity of TF in macrophages and endothelial cells; GSDMD mediates NETs formation; pyroptosis in endothelial cells and platelets affects hemostasis; the release of proinflammatory cytokines promotes hemostasis activation.