Furthermore, a recent study showed that in a bacterial infection mouse model (cecal ligation and puncture, CLP), activation of transmembrane protein 173 (TMEM173, also known as stimulator of interferon response cGAMP interactor, [STING]) triggered TF release and mediated coagulation activation, which relied on calcium release from the endoplasmic reticulum (77). The gene discussed is STING1; the disease is bacterial infectious disease.