In vivo profiles were derived from patients administered an intravenous bolus injection of LPS for 1-6h (human endotoxemia model), followed by isolation of cells from serum, either as total neutrophil populations or as subpopulations sorted for CD16 and CD62L expression levels, markers of neutrophil maturity (21, 24, 25). This evidence concerns the gene SELL and serum lipopolysaccharide activity.