HMGB1 and neoplasm: The delayed release of HMGB1 and accumulation of 4-HNE (seen with ferroptosis) that occurs in tumor regions distant from the ablation zone are temporally and spatially distinct from the early release of HMGB1 and co-localization of pRIPK3 and pMLKL (seen with necroptosis) that occurs in tumor regions adjacent to the ablation zone.