Then, based on the fact that IR induces DNA damage and triggers apoptosis in RMS cells as well as other cancer cell types (Codenotti et al., 2021; Rossetti et al., 2021; Liu et al., 2022), that SPM has a protective effect against DNA damage induced by IR (Douki et al., 2000), and that SPM levels drop when SMOX expression is forced, we have evaluated whether combining IR with SMOX overexpression could be a good strategy to kill FN-RMS cells. This evidence concerns the gene SMOX and cancer.