Upregulated ATAC peaks included for instance the HLA-C gene locus (Figure 6A) whereas the group of genes associated with ISX-downregulated ATAC peaks encompassed important NB disease genes such as MYCN, ALK or NTN3 (37), which were accordingly transcriptionally repressed by the drug (Figure 6B and Supplementary Figure S7B). Here, ALK is linked to neuroblastoma.