MYCN and neuroblastoma: Upregulated ATAC peaks included for instance the HLA-C gene locus (Figure 6A) whereas the group of genes associated with ISX-downregulated ATAC peaks encompassed important NB disease genes such as MYCN, ALK or NTN3 (37), which were accordingly transcriptionally repressed by the drug (Figure 6B and Supplementary Figure S7B).