IGHE and allergic disease: While interaction of IgE-Ag complexes with FcεRI elicits cellular degranulation process and accounts for immediate hypersensitivity reactions and the induction of clinical symptoms of allergy, the binding between IgE and CD23 has been reported to be involved in Ag presentation, and the transport of antigens across airway and intestinal epithelial barriers (Gasser et al., 2020).