IgE directed against autoantigens were observed in a number of autoimmune conditions, including SLE (Atta et al., 2010), BP (van Beek et al., 2016), chronic spontaneous urticaria (CSU) (Panaszek et al., 2017), AITD (Guo et al., 1997), multiple sclerosis (Seals et al., 2022), and mixed connective tissue disease (Lamri et al., 2021). Here, IGHE is linked to systemic lupus erythematosus.