Although until recently the majority of pathogenic autoantibodies in SLE was considered to be of the IgG class (Villalta et al., 2013; Dema and Charles, 2016), the study by Charles et al. showed that the presence of autoreactive IgE in SLE subjects was also associated with increased basophil activation and enhanced disease activity (Charles et al., 2010). Here, IGHE is linked to systemic lupus erythematosus.