While in patients with allergic diseases IgE is directed against allergens, in patients with SLE IgE autoantibodies react mainly with nucleic antigens and are capable of triggering IFN-mediated responses through TLR7 and TLR9, while IgE against allergens lacks this property (Sanjuan et al., 2016). The gene discussed is TLR9; the disease is systemic lupus erythematosus.