IGHE and systemic lupus erythematosus: In a multicentre study of 196 SLE patients, approximately 65% had IgE antibodies to the seven autoantigens tested, and the positivity increased to almost 83% when only those subjects with active disease were considered (total vs. active disease: dsDNA 35,4% vs. 62%, Sm 7.5% vs. 6.1%, SS-A/Ro 8.5% vs. 4.1%, SS-B/La 4.1% vs. 0,2%) (Dema et al., 2014b).