Interestingly, the relative absence of allergic diseases among ALPS patients with high IgE levels suggests an association between IgE production and autoimmunity that is independent of allergy, and could be a result of Ag‐independent differentiation of unconventional germinal center B cells into IgE‐producing plasma cells (Butt et al., 2015). The gene discussed is IGHE; the disease is allergic disease.