It is worth to note that pDCs produce 200 to 1000 times more IFN than other blood cells (Siegal et al., 1999), and INF-α has been found to inhibit degranulation of eosinophils, histamine release in mast cells, prevent IL-3-mediated priming of basophils, and reduce allergic responses by preventing GATA3 from enhancing its own expression in T cells, thus in patients with SLE with IgE antibodies allergies may not be common (Sanjuan et al., 2016). The gene discussed is IGHE; the disease is allergic disease.