ESR1 and colonic neoplasm: These 19 crucial targets with higher DC values were identified as the candidate targets of FMNT and CS against colon cancer, including AKT1, TP53, MAPK3, EGFR, HSP90AA1, ESR1, MYC, CASP3, TNF, JUN, PTEN, MAPK1, FOS, RELA, FN1, PTGS2, HSP90AB1, MAPK8 and PPARG (Figure 2D).