The significant pathways mainly included hepatitis C, pathways in cancer, hepatitis B, MAPK signaling pathway, prostate cancer, PI3K-Akt signaling pathway, toxoplasmosis and apoptosis, etc. It further showed that 42 and 46 targets were involved in the MAPK (ko04010) and PI3K-Akt (ko04151) signaling pathways, respectively (Figure 4C). Here, AKT1 is linked to hepatitis B virus infection.