PTGS2 and neoplasm: What is more, HQ exerted potent anti-tumor activity through simultaneous modulation of mammalian target of rapamycin (mTOR) and cyclooxygenase-2 (COX-2) signaling, which together decreased vascular endothelial growth factor (VEGF) expression to effectively suppress angiogenesis in tumor xenograft and human colon cancer cells (Auyeung et al., 2016).