In addition to FMNT, CS could notably inhibited proliferation and induced apoptosis of colon cancer cells through regulating multiple signaling, including ERβ/MiR-95, ERβ/miR-17, IGF-1R and PI3K-Akt signaling pathways (Chen et al., 2015b; Zhao et al., 2016), which indicates that CS serves as an attractive chemotherapeutic agent against colon cancer. This evidence concerns the gene ESR2 and malignant colon neoplasm.