PRRT2 and diabetes mellitus: With the gradual deepening of the research on diabetes, many evidence supports that hyperglycemia causes tissue damage mainly through five mechanisms: (1) increased intracellular formation of advanced glycation end-products (AGEs); (2) increased expression of the receptor for advanced glycation end products and its activating ligands; (3) increased flux of glucose and other sugars through the polyol pathway; (4) activation of protein kinase C (PKC) isoforms; and (5) overactivity of the hexosamine pathway.