Taking into account the high TRIC-B homology in teleosts and mammals and the suitability of zebrafish as a model for dominant and recessive OI forms (23, 25, 51), we targeted zebrafish tmem38b by CRISPR/Cas9 both to understand the role of Tric-b in D. rerio and to generate the first teleost model for the human disease. Here, TMEM38B is linked to osteogenesis imperfecta.