While alterations in the secretory pattern of LH have been characterized extensively in women with PCOS, for obvious reasons, tissue-specific processes associated with LH hypersecretion are difficult to be determined; therefore, animal models of PCOS provide unparalleled resources to investigate cellular and molecular mechanisms at the hypothalamo-pituitary axis that underlie the neuroendocrine dysfunction. The gene discussed is PLOD1; the disease is polycystic ovary syndrome.