Moreover, while testosterone administration does not increase LH pulse frequency in women (9), androgen antagonist therapy re-establishes the ability of estradiol and progesterone to suppress LH pulsatility in PCOS patients (10), suggesting that hyperandrogenism does not directly drive LH hypersecretion, but instead it reduces the ability of ovarian steroids to suppress LH. The gene discussed is PLOD1; the disease is hyperandrogenism.