The renin-angiotensin-aldosterone system (RAAS) signaling and angiotensin-converting enzyme 2 (ACE2) have been implicated in the pathogenesis of COVID-19 because ACE2 – an enzyme that physiologically counteracts RAAS activation, is a functional receptor for SARSCoV-2 – the virus responsible for the Covid-19 pandemic (1). The gene discussed is ACE2; the disease is COVID-19.