IGF1 and hydrops fetalis: Amongst the main identified biological targets that induce HF regeneration are the Wnt/β-catenin cascade and growth factors such fibroblast growth factor (FGF), vascular endothelial growth factor (VEGF), transforming growth factor β (TGF-β), insulin-like growth factor (IGF), endothelial cell growth factor (ECGF), and epidermal growth factor (EGF) (57, 58).