Another study showed that lipid peroxidation and ROS generation were significantly increased in cisplatin-induced acute kidney injury (cis-AKI), and the expression level of GPX4 was downregulated in Vitamin D receptor knockout mice, promoting the occurrence of ferroptosis in renal tubular epithelial cells and aggravating renal tissue injury caused by cisplatin (50). The gene discussed is VDR; the disease is acute kidney injury.