Hyperactivation of STAT5 is also associated with other blood malignancies such as acute lymphoblastic leukemia (ALL), chronic myelogenous leukemia (CML), myeloproliferative neoplasms (MPNs), in addition to human tumors (breast, prostate, liver, etc.), and other cancers (5). The gene discussed is STAT5A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.