For example, Coxsackievirus B3 (CVB3) mediated cytotoxicity in lung cancer cells with high CRT exposure, HMGB1 release, and ATP secretion (58), whereas CVA21 mediated cytotoxicity in bladder cancer cells positively correlated with high CRT exposure and HMGB1 release but not ATP release (59). The gene discussed is HMGB1; the disease is lung cancer.