Pharmacological inhibition or shRNA-mediated depletion of STAT3 suppressed the NDV/FMW-caused ICD determinants, including HMGB1 and HSP70/90 release, CRT exposure, and ATP secretion (61), suggesting plausible mechanisms to fine-tune NDV-induced ICD in diverse cancer types. This evidence concerns the gene HMGB1 and impulse control disorder.