T-VEC was shown to induce apoptosis in melanoma cells (83) and trigger ICD hallmarks including ecto-CRT, HMGB1, and ATP release (74, 75), resulting in the recruitment of tumor-specific CD8+ T cells and induction of proinflammatory responses in both injected and non-injected tumor sites (74). This evidence concerns the gene HMGB1 and neoplasm.