It was found that 6 DETFs had significant effects on the prognosis of HCC patients, namely DACH1, FOSB, FOS, ASCL1, EBF1, and GTF2H2. The high expressions of GTF2H2 and DACH1 were associated with poor prognosis of patients, while high expressions of FOSB, ASCL1, EBF1, and FOS had a better OS probability. The gene discussed is FOSB; the disease is hepatocellular carcinoma.