PTPRZ1 SNPs significantly associating with the risk to develop schizophrenia have been reported (Buxbaum et al., 2008) but the gene’s link with Alzheimer’s Disease thus far is based on expression levels of RPTPζ isoforms and of its ligand pleiotrophin in postmortem material (Zhao et al., 2021). Here, PTPRZ1 is linked to schizophrenia.