Nephron functionality apparently is very vulnerable because many different podocyte-related genes have been uncovered as monogenetic cause of nephrotic syndromes, and mutant PTPRO alleles are regularly detected (Trautmann et al., 2018; Thakor et al., 2021), although this could be population dependent (Al-Hamed et al., 2013). The gene discussed is PTPRO; the disease is nephrotic syndrome.