It should therefore not come as a surprise that PTPN14 variants have been linked to cancer predispositions (Zhang et al., 2016b; Olafsdottir et al., 2021) as well as malformations, including gingival fibromatosis with distinctive facies (Cogulu et al., 2021), lymphedema-posterior choanal atresia syndrome (Au et al., 2010; Bordbar et al., 2017) and hereditary hemorrhagic telangiectasia 1 (Benzinou et al., 2012; Letteboer et al., 2015). The gene discussed is PTPN14; the disease is cancer.