Gene PTPRJ was considered a suspect tumor suppressor early on, based on findings in cell models and mutant mice that collectively pointed to a role for the gene in vascular development and colon cancer susceptibility, and for the encoded protein (CD148, also known as density-enhanced phosphatase-1 or DEP-1) in the mechanism of cell contact growth inhibition (https://atlasgeneticsoncology.org/gene/41932/ptprj-(protein-tyrosine-phosphatase-receptor-type-j)). Here, PTPRJ is linked to colonic neoplasm.