For another SNP in PTPRC, rs10919563 that resides within an intron further downstream in the gene, it is as yet unclear how this mechanistically may impact on immune cell functioning, but multiple reports have hinted at an association with autoimmune diseases such as familial rheumatoid arthritis, systemic lupus erythematosus and primary Sjögren’s syndrome (Tchilian and Beverley, 2006; Al Barashdi et al., 2021). This evidence concerns the gene PTPRC and autoimmune disease.