Candidacy as a contributor to heritable colorectal cancer susceptibility (de Voer et al., 2016; Belhadj et al., 2020) and recently the risk to develop hepatocellular carcinomas has been reported (Shen et al., 2020a), but a meta-analysis of proposed colorectal cancer predisposition genes rather called for caution in claiming cancer risk candidacy, including that of PTPN12 (Broderick et al., 2017; Terradas et al., 2020). The gene discussed is PTPN12; the disease is colorectal cancer.