Given PTPN13’s pronounced expression in normal colon and gut tissue, authors probed for a contributing role of the phosphatase in HSCR etiology, but no further PTPN13 mutations were apparent in the cohort of 83 patients, and PTPN13 protein levels appeared normal in colon tissue from 16 of them (Zhang et al., 2017). The gene discussed is PTPN13; the disease is Hirschsprung disease.