Occasionally deletions, but mostly missense mutations and transcriptional silencing by means of interfering RNAs (notably the long non-coding RNA transcribed from PTPRG-AS1 that overlaps with the last exons in PTPRG) or promoter hypermethylation were found, and a comprehensive review of PTPRG’s role in cancer has recently been published (Boni and Sorio, 2021). This evidence concerns the gene PTPRG and cancer.