The FDX1 expression was further analyzed in Pan cancer in TCGA database, and the FDX1 expression was lower in tumor tissues than in normal tissues in breast cancer (BRCA), Cholangio carcinoma (CHOL), Colon adenocarcinoma (COAD), Kidney Chromophobe (KICH), Kidney renal clear cell carcinoma (KIRC), Kidney renal papillary cell carcinoma (KIRP), Lung Adenocarcinoma (LUAD), Lung Squamous cell carcinoma (LUSC), Prostatic cancer (PRAD), Rectum adenocarcinoma (READ) and Thyroid carcinoma (THCA) (p < 0.05). The gene discussed is FDX1; the disease is thyroid gland carcinoma.