HDAC7 and Onset: Although we did not determine that HDAC7 was significantly associated with POMS in this study, the rare variant previously identified as associated with adult-onset MS within HDAC7 (chr12:48191247) had a similar MAF among POMS cases (1.5%) compared to previously reported adult-onset MS cases and controls (1.4%).4 The MAF among POMS controls was 2.0%.