From the pathological perspective, LeBleu et al.15explained the role of HE‐4 in the development of renal fibrosis and found that HE‐4 downregulated the activity of several kinds of proteases, including serine proteases and metalloproteinases, leading to an inhibition of their capacity to degrade type I collagen. This evidence concerns the gene WFDC2 and renal fibrosis.