However, as reported in other studies, patients with other mutations in the FGFR2 gene manifested with other phenotypes: patients with the c.1012G > C p.G338R mutation manifested with the phenotype of ocular proptosis, shallow orbits, and mid-face hypoplasia; patients with the mutation c.866A > C (Gln289Pro) in this gene manifested with the phenotype of shallow orbits and ocular proptosis, accompanied by mid-face hypoplasia, craniosynostosis, and clinically normal hands and feet. Here, FGFR2 is linked to craniosynostosis.