Univariate analyses showed that FAR, gender, HR, SBP, smoking history, hypertension, NT-proBNP, white blood cells, NLR, MLR, PLR, hs-CRP, ALT, AST, albumin, creatinine, cystatin C, eGFR, serum Na+, serum Ca2+, HCY, PT, PTA, INR, APTT, FIB, d-dimer, FDP, triglycerides, Lp(a), Gensini score, initial diagnosis (STEMI), Killip class(≥ III) and plaque property were risk factors for LVSD in ACS patients after PCI (all P < 0.05). The gene discussed is CST3; the disease is Hypertension.