ACAN and intervertebral disk degenerative disorder: Meanwhile, intermittent injection of PTH could significantly attenuate disc degeneration in aged mice and improve intervertebral disc height and volume by increasing the levels of TGF‐β activity, CCN2, and aggrecan.[50] In our study, we found that PTH did benefit the preservation of hyaline cartilage formation after induction with MSC chondrogenic medium.