From a clinical stand point, while the hyperreflective RPE line in 12-month-old WT-, Thbs1−/−-, and Cd47−/−-mice was clearly visible in OCT examination (blue arrows Fig. 2L–N), HRFs above the RPE line were only observed in age-matched Cd47−/−-mice (red arrows, Fig. 2N), in the exact location and size that retinal melanosomes had been observed (Figs. 2C–E, 3E–H, K), and with striking similarities to HRF observed in AMD (Fig. 1B). Here, THBS1 is linked to age-related macular degeneration.