RPE65 and age-related macular degeneration: Immunostaining for RPE65 and peropsin, two RPE-specific proteins, stained the RPE mono-layer of healthy control donors red in bright-field observation (insets Fig. 1G and H) and strongly marked the RPE in AMD sections visible in bright field and in red fluorescence, but failed to stain any pigmented foci of the retina (Fig. 1G and H).