THBS1 and age-related macular degeneration: However, there was a remarkable difference between the two knockout mouse strains: in Cd47−/−-mice the cell bodies of subretinal MPs were bloated with a dense pigment, which SBF-SEM reveals was due to densely packed intracellular melanosomes/melanolipofuscin particles, only rarely observed in Thbs1−/−-mice (Figs. 2 and 3) and with striking similarities to melanophages in the dermis of mice [28] and the retinae of AMD patients (Fig. 1).