APOE and atherosclerosis: In order to further explore the effect of AI662270 on atherosclerosis, 8-week-old athero-prone ApoE−/− mice were randomly divided into 2 groups: ApoE−/− mice intravenously injected with recombinant lentivirus vector expressing AI662270 (Lv-AI662270) and empty vector (Lv-null), and fed with HFD for 16 weeks (Fig. 1F).