Integrating TWAS and mRNA expression profiling data revealed several candidate genes associated with JIA, and compared to previous studies, in the present study, we identified some novel genes that may play a potential role in the pathogenesis of JIA, such as ANXA3, GPR146, ANKRD9, and TMEM158. Reportedly, ANXA3 contributes to cancer development via the NF-κB pathway [39]. Here, GPR146 is linked to cancer.