Some studies have shown that GPR146 deficiency reduces lipids and prevents atherosclerosis [41], and the study by Clarke et al. found that genetic susceptibility to juvenile idiopathic arthritis is associated with multiple cardiovascular risk factors [42], supporting the hypothesis of increased cardiovascular risk in juvenile idiopathic arthritis, suggesting that GPR146 may be associated with the development of JIA. The gene discussed is GPR146; the disease is juvenile idiopathic arthritis.