β-Naphthoflavone is present in cigarette smoke condensate, and Adachi et al. found that cigarette smoke condensate can lead to AhR-dependent NF-κB activation and activate related pathways, thereby inducing the production of the pro-inflammatory factor IL-1β in synoviocytes of patients with rheumatoid arthritis [52]. This evidence concerns the gene NFKB1 and rheumatoid arthritis.