KDM4B and cancer: Glucose starvation-induced p-ERK phosphorylates and interacts with the demethylase JMJD2B (jumonji domain-containing protein 2B) to prevent its ubiquitination-related degradation, thereby reducing the abundance of the repressive H3K9me3 levels on the GLUT1 promoter to increase GLUT1 expression and prevent cancer cell death[27].