To accurately predict clinical outcomes based on m6A methylation-associated prognostic lncRNAs in patients with COAD, we performed least absolute shrinkage and selection operator (LASSO) analysis of 43 m6A methylation-associated prognostic lncRNAs in TCGA training cohort, which revealed 13 prognostic predictive signatures: AC092944.1, AL137782.1, U91328.1, AC073896.3, ATP2B1-AS1, AL391095.2, SEPTIN7-DT, AC104819.3, LINC00861, AC003101.2, AC005229.4, AC156455.1, and AP001628.1. Here, SEPTIN7 is linked to colon adenocarcinoma.