HPCAL4 and Alzheimer disease: In addition, common deregulated proteins in AD women and men (TAGLN3, PDE2A, GAP43, CAMK2A, HPCAL4, CAMK2B, SGIP1, CAMK2G, YWHAG, DPYSL4, VIM, LGALS3, HSPB1 and GFAP) are differentially expressed in AD mouse models before AD pathology appears (Additional file 4: Table S4), which may be considered early alterations during the neurodegenerative process.