In addition, common deregulated proteins in AD women and men (TAGLN3, PDE2A, GAP43, CAMK2A, HPCAL4, CAMK2B, SGIP1, CAMK2G, YWHAG, DPYSL4, VIM, LGALS3, HSPB1 and GFAP) are differentially expressed in AD mouse models before AD pathology appears (Additional file 4: Table S4), which may be considered early alterations during the neurodegenerative process. This evidence concerns the gene TAGLN3 and Alzheimer disease.