Blood pressure was 146 (IQR, 130–150) mmHg in the group of dogs without MMVD, 142 (IQR, 130–147.5) mmHg in the group of normotensive dogs with MMVD stage B, and 174 (IQR, 169–185) mmHg in the group of dogs with systemic hypertension with MMVD stage B: Systemic hypertensive dogs with MMVD had significantly higher blood pressure than dogs without MMVD and normotensive dogs with MMVD (p < 0.001among groups).; the corresponding measured NT-proBNP concentrations were 504 (IQR, 430–774) pmol/L, 1083.5 (IQR, 574.8–1912.8) pmol/L, and 2345.0 (IQR, 1812.5–2533.0) pmol/L, respectively. The gene discussed is NPPB; the disease is Hypertension.