EGFR and lung cancer: In our study, we detected the most frequent genetic mutations in EGFR (58%), higher than the recent genomic studies in brain oligometastatic lung cancer (44%-47%) [30] and LUAD in Chinese (50%) [31], East Asian (47%) [32], MSKCC (33%) [33] cohorts, and the discrepancy may be due to the association of EGFR mutations with promotion of bone metastasis [34] and ethnic differences between eastern and western populations.