Our research found that SERPINE1 might affect the pathogenesis of colon cancer by influencing cell adhesion, kinase activation and other pathways, and thus we further studied the kinases, miRNAs and transcription factors related to SERPINE1. Kinases play a pivotal role in the pathogenesis of cancer and research suggested that the activation of the tyrosine kinase pathway can stimulate the pathogenesis of colon cancer [32]. This evidence concerns the gene SERPINE1 and cancer.