Subsequently, it was found through the LinkedOmics database that there were a great number of genes associated with the expression of SERPINE1, wherein the expression of ITGA5, MMP19 and ADAMTS4 was the most pronouncedly related to the expression of SERPINE1. ITGA5 is integrin subunit α5, and there are little published data on proving that relationship between SERPINE1 and the expression of ITGA5, while it is reported that overexpression of ITGA5 can promote the metastasis and spread of colon cancer [25]. Here, ADAMTS4 is linked to malignant colon neoplasm.