It is widely thought that at the cancerous site, TIPE3 is stimulated by the tumor environment, resulting in a higher TIPE3 expression, which in turn accelerates the transport rates of PIP2 and PIP3, two lipid second messengers; this activates the PI3K/AKT and MEK-ERK signaling pathways, which further promotes the growth, proliferation, and migration of tumor cells, accounting for the malignancy and poor prognosis. Here, TIPE3 is linked to neoplasm.