In human non-small-cell lung cancer (NSCLC), some researchers have found that the expression of TIPE3 on the plasma membrane is positively correlated with the T stage of NSCLC, indicating that TIPE3 located in the plasma membrane may play a role in promoting tumor development, whereas cytoplasmic TIPE3 may exert a negative effect [10]. Here, TIPE3 is linked to non-small cell lung carcinoma.