It is known that envelope glycoproteins including gp120 can bind to their cellular receptors and chemokine coreceptors prior to viral fusion and entry, and cause bystander CD4+ T‐cell death.[12, 22] This is considered a critical element of HIV pathogenesis given that it contributes to the selective depletion of CD4+ T cells and leads to immunodeficiency.[12, 22] The constructed MLN, MPLN, and MPLN with scrambled siRNA markedly improved the viability of bystander T cells. This evidence concerns the gene ITIH4 and immune system disorder.