In addition, RSPO4 p.L54H and SFRP5 p.P232Q mutations were enriched in controls, and the WNT10A p.R171C mutation has been repeatedly reported to highly predispose to non‐syndromic tooth agenesis but not adiposity.[19] Therefore, RSPO1 p.R219W together with p.R219Q mutations identified at the same site were further investigated (Table1). Here, RSPO4 is linked to tooth agenesis.