MC4R and obesity due to melanocortin 4 receptor deficiency: We also examined in these carriers the low‐frequency/rare variants in other reported genes that cause obesity in literature.[48] We found that two cases additionally carried an SNP (rs1805094, p.K656N) in LEPR gene, and one case carried an SNP (rs2229616, p.V103I) in MC4R gene, while the others did not carry any combined mutations.