The AUC of copeptin has previously been found to be 0.845 for predicting sepsis or septic shock with a cut-off of 23.2 pmol/l, with 74% sensitivity and 87% specificity.29 Serum APOA5 level exhibited an AUC of 0.753 (95% CI, 0.654–0.852) with a sensitivity of 55.56% and a specificity of 86.67%.15 The combined use of PSP and CRP improved the accuracy to 0.79 (95% CI, 0.72–0.86) with a cut-off point of 290.5 ng/ml for PSP and 167.2 mg/l for CRP for the prediction of sepsis.20 The gene discussed is APOA5; the disease is Sepsis.