The MACE-sequencing results showed that the gene of MMP11 (p-value = 0.004) and COL1A1 (p-value = 0.0001) in BC tissues were significantly up-regulated as compared to the normal tissues and also the expression level of TP53 (p-value = 0.001), and TP53INP1 (p-value = 0.02) was significantly down-regulated (Fig. 4B). Here, TP53 is linked to breast cancer.