Water consumption also statistically increased 3 months after diabetes induction in compare to NDC group (male: p < 0.0001, female: p < 0.001) and insulin or MgSO4 therapy could considerably decrease water intake in the both parents, however only in the female Mg-treated and insulin-treated groups the water consumption get to the female NDC group (Fig. 4b). This evidence concerns the gene INS and diabetes mellitus.