Such MYC-driven lymphomas can be modelled pre-clinically using the Eμ-Myc transgenic mouse model, which recapitulates the immunoglobulin/c-MYC chromosomal translocation characteristic of BL, and results in pre-B/B cell lymphomas with almost 100% incidence [17]. The gene discussed is MYC; the disease is B-cell non-Hodgkin lymphoma.