IRF7 and viral infectious disease: We previously reported that, in the context of other viral infections (i.e., various RNA genome viruses such as Dengue, Chikungunya, Hepatitis C, Zika viruses), contact with infected cells similarly induced a IRF7/IFN-I/λ prioritized signaling in activated pDCs, as opposed to incubation of pDCs with cell-free viruses49,70.